Seema Lalani, MD




ABMG Certified Clinical Cytogeneticist

 

POSITIONS

Associate Professor
Molecular and Human Genetics
Baylor College of Medicine
Houston, TX, US

Assistant Laboratory Director
Cytogenetics Laboratory
Baylor Genetics

EDUCATION

MD from Aga Khan University Medical College
01/1994 - Karachi, Pakistan

Residency at Milton S Hershey Medical Center
01/1996 - Hershey, Pennsylvania, United States
Pediatrics

Clinical Fellowship at Baylor College Of Medicine
01/1999 - Houston, TX, United States
Medical Genetics

Clinical Fellowship at Baylor College Of Medicine
01/2004 - Houston, Texas, United States
Clinical Cytogenetics

CERTIFICATIONS

General Pediatrics
American Board of Pediatrics

Clinical Genetics
American Board of Medical Genetics

Clinical Cytogenetics
American Board of Medical Genetics

PROFESSIONAL INTERESTS

• Copy number variations and diseases, congenital cardiovascular malformations, genetic causes of language/speech delay

SELECTED PUBLICATIONS

• Probst FJ, James RA, Burrage LC, Rosenfeld JA, Bohan TP, Ward Melver CH, Magoulas P, Austin E, Franklin AI, Azamian M, Xia F, Patel A, Bi W, Bacino C, Belmont JW, Ware SM, Shaw C, Cheung SW, Lalani SR. "De novo deletions and duplications of 17q25.3 cause susceptibility to cardiovascular malformations.." Orphanet J Rare Dis.. 2015 June 14;10:75. Pubmed PMID: 26070612
• Szafranski P, Von Allmen GK, Graham BH, Wilfong AA, Kang SH, Ferreira JA, Upton SJ, Moeschler JB, Bi W, Rosenfeld JA, Shaffer LG, Wai Cheung S, Stankiewicz P, Lalani SR. "6q22.1 microdeletion and susceptibility to pediatric epilepsy." Eur J Hum Genet. 2015 February;23:173-9. Pubmed PMID: 24824130
• Parrott A, James J, Goldenberg P, Hinton RB, Miller E, Shikany A, Aylsworth AS, Kaiser-Rogers K, Ferns SJ, Lalani SR, Ware SM. "Aortopathy in the 7q11.23 microduplication syndrome." Am J Med Genet A. 2015 February;167:363-70. Pubmed PMID: 25428557
• Lalani SR, Belmont JW. "Genetic basis of congenital cardiovascular malformations." Eur J Med Genet. 2014 August;57(8):402-13. Pubmed PMID: 24793338
• Lalani SR, Zhang J, Schaaf CP, Brown CW, Magoulas P, ..., Eng CM, Lupski JR, Gibbs RA, Beaudet AL, Yang Y, Wang MC, Xia F. "Mutations in PURA cause profound neonatal hypotonia, seizures, and encephalopathy in 5q31.3 microdeletion syndrome." Am J Hum Genet. 2014 November 6;95:579-83. Pubmed PMID: 25439098
• Lalani SR, Ware SM, Wang X, Zapata G, ..., Fernbach SD, Potocki L, Belmont JW. "MCTP2 is a dosage-sensitive gene required for cardiac outflow tract development.." Hum Mol Genet.. 2013;22(21):4339-48. Pubmed PMID: 23773997
• Wiszniewski W, Hunter JV, Hanchard NA, Willer JR, Shaw C, Tian Q, Illner A, Wang X, (.....), Lalani SR. "TM4SF20 Ancestral Deletion and Susceptibility to a Pediatric Disorder of Early Language Delay and Cerebral White Matter Hyperintensities." Am J Hum Genet.. 2013 August 8;93(2):197-210. Pubmed PMID: 23810381
• Lalani SR, Shaw C, Wang X, Patel A, Patterson LW, Kolodziejska K, Szafranski P, Ou Z, Tian Q, Kang SH, Jinnah A, Ali S, Malik A, Hixson P, Potocki L, Lupski JR, Stankiewicz P, Bacino CA, Dawson B, Beaudet AL, Boricha FM, Whittaker R, Li C, Ware SM, Cheung. "Rare DNA copy number variants in cardiovascular malformations with extracardiac abnormalities.." Eur. J. Hum. Genet.. 2013 February;21(2):173-81. Pubmed PMID: 22929023
• Lalani SR, Hefner MA, Belmont JW, Davenport SLH. "CHARGE Syndrome." In: Pagon RA, Adam MP, Ardinger HH, Wallace S. 2012 February 2 Pubmed PMID: 20301296
• Liu P, Erez A, Nagamani SC, Dhar SU, Kolodziejska KE, Dharmadhikari AV, Cooper ML, Wiszniewska J, Zhang F, Withers MA, Bacino CA, Campos-Acevedo LD, Delgado MR, Freedenberg D, Garnica A, Grebe TA, Hernández-Almaguer D, Immken L, Lalani SR, McLean SD, Nort. "Chromosome catastrophes involve replication mechanisms generating complex genomic rearrangements.." Cell. 2011 September 16;146(6):889-903. Pubmed PMID: 21925314
• Layman WS, McEwen DP, Beyer LA, Lalani SR, Fernbach SD, Oh E, Swaroop A, Hegg CC, Raphael Y, Martens JR, Martin DM. "Defects in neural stem cell proliferation and olfaction in Chd7 deficient mice indicate a mechanism for hyposmia in human CHARGE syndrome.." Hum. Mol. Genet.. 2009 June 1;18(11):1909-23. Pubmed PMID: 19279158
• Lalani SR, Thakuria JV, Cox GF, Wang X, Bi W, Bray MS, Shaw C, Cheung SW, Chinault AC, Boggs BA, Ou Z, Brundage EK, Lupski JR, Gentile J, Waisbren S, Pursley A, Ma L, Khajavi M, Zapata G, Friedman R, Kim JJ, Towbin JA, Stankiewicz P, Schnittger S, Hansman. "20p12.3 microdeletion predisposes to Wolff-Parkinson-White syndrome with variable neurocognitive deficits.." J. Med. Genet.. 2009 March;46(3):168-75. Pubmed PMID: 18812404
• Brunetti-Pierri N, Berg JS, Scaglia F, Belmont J, Bacino CA, Sahoo T, Lalani SR, Graham B, Lee B, Shinawi M, Shen J, Kang SH, Pursley A, Lotze T, Kennedy G, Lansky-Shafer S, Weaver C, Roeder ER, Grebe TA, Arnold GL, Hutchison T, Reimschisel T, Amato S, Ge. "Recurrent reciprocal 1q21.1 deletions and duplications associated with microcephaly or macrocephaly and developmental and behavioral abnormalities.." Nat. Genet.. 2008 December;40(12):1466-71. Pubmed PMID: 19029900
• Lalani SR, Safiullah AM, Fernbach SD, Harutyunyan KG, Thaller C, Peterson LE, McPherson JD, Gibbs RA, White LD, Hefner M, Davenport SL, Graham JM, Bacino CA, Glass NL, Towbin JA, Craigen WJ, Neish SR, Lin AE, Belmont JW. "Spectrum of CHD7 mutations in 110 individuals with CHARGE syndrome and genotype-phenotype correlation.." Am. J. Hum. Genet.. 2006 February;78(2):303-14. Pubmed PMID: 16400610

MEMBERSHIPS

Society of Pediatric Research
Member

American Society of Human Genetics
Member