Lee-Jun Wong, PhD




Molecular and Human Genetics
Baylor College of Medicine
Houston, TX, US

Vice President, Sr. Lab Director
Baylor Miraca Genetics Laboratories

Program in Translational Biology & Molecular Medicine
Baylor College of Medicine


PhD from Ohio State University
03/1975 - Columbus, OH, United States

Postdoctoral Fellowship at Princeton University
02/1976 - Princeton, NJ, United States

BS from National Taiwan University
06/1971 - Taipei, Taiwan


Clinical Biochemical Genetics
American Board of Medical Genetics

Clinical Molecular Genetics
American Board of Medical Genetics


• Mitochondrial genetics and function in human diseases, cancer, and aging


• Wang J, Yu H, Zhang VW, Tian X, Feng YM, Wang G, Gorman E, Wang H, Lutz RE, Schmitt ES, Peacock S, Wong LJ. "Capture based high coverage NGS: a powerful tool to uncover a wide spectrum of mutation types." Genet. Med.. 2015 September 24 Pubmed PMID: 26402642
• Li J, Dai H, Feng Y, Tang J, Chen S, Tian X, Gorman E, Schmitt ES, Hansen T, Wang J, Plon SE, Zhang VW, Wong LJ. "A comprehensive strategy for accurate mutation detection of the highly homologous PMS2 gene." J Mol Diagn. 2015 September;17:545-53. Pubmed PMID: 26320870
• Gargis AS, Kalman L, Bick DP, da Silva C, Dimmock DP, Funke BH, ..., Wong LJ, Zehnbauer BA, Zook JM, Lubin IM. "Good laboratory practice for clinical next-generation sequencing informatics pipelines." Nat Biotechnol. 2015 July 8;33:689-93. Pubmed PMID: 26154004
• Zhou S, Hertel PM, Finegold MJ, Wang L, Kerkar N, Wang J, Wong LC, Plon SE, Sambrotta M, Foskett P, Niu Z, Thompson RJ, Knisely AS. "Hepatocellular carcinoma associated with tight-junction protein 2 deficiency." Hepatology. 2015 April 29 Pubmed PMID: 25921221
• Feng Y, Chen D, Wang GL, Zhang VW, Wong LJ. "Improved molecular diagnosis by the detection of exonic deletions with target gene capture and deep sequencing." Genet Med. 2015 February;17:99-107. Pubmed PMID: 25032985
• Tannour-Louet M, York B, Tang K, Stashi E, Bouguerra H, Zhou S, Yu H, Wong LJ, Stevens RD, Xu J, Newgard CB, O'Malley BW, Louet JF. "Hepatic SRC-1 activity orchestrates transcriptional circuitries of amino acid pathways with potential relevance for human metabolic pathogenesis." Mol Endocrinol. 2014 October;28:1707-18. Pubmed PMID: 25148457
• Wang J, Zhang VW, Feng Y, Tian X, Li FY, Truong C, Wang G, Chiang PW, Lewis RA, Wong LJ. "Dependable and efficient clinical utility of target capture-based deep sequencing in molecular diagnosis of retinitis pigmentosa." Invest Ophthalmol Vis Sci. 2014 August;55:6213-23. Pubmed PMID: 25097241
• Dallabona C, Diodato D, Kevelam SH, Haack TB, Wong LJ, ..., Vanderver A, Ghezzi D, van der Knaap MS. "Novel (ovario) leukodystrophy related to AARS2 mutations." Neurology. 2014 June 10;82:2063-71. Pubmed PMID: 24808023
• Balmer C, Pandey AV, Rüfenacht V, Nuoffer JM, Fang P, Wong LJ, Häberle J. "Mutations and polymorphisms in the human argininosuccinate lyase (ASL) gene." Hum Mutat. 2014 January;35:27-35. Pubmed PMID: 24166829
• Gai X, Ghezzi D, Johnson MA, Biagosch CA, Shamseldin HE, Haack TB, Reyes A, Tsukikawa M, Sheldon CA, Srinivasan S, Gorza M, Kremer LS, Wieland T, Strom TM, Polyak E, Place E, Consugar M, Ostrovsky J, Vidoni S, Robinson AJ, Wong LJ, ..., Falk MJ, Zeviani M. "Mutations in FBXL4, Encoding a Mitochondrial Protein, Cause Early-Onset Mitochondrial Encephalomyopathy.." Am J Hum Genet.. 2013;93(3):482-95. Pubmed PMID: 23993194
• Wong LJ. "Next generation molecular diagnosis of mitochondrial disorders.." Mitochondrion. 2013 July;13(4):379-87. Pubmed PMID: 23473862
• Kaipparettu BA, Ma Y, Park JH, Lee TL, Zhang Y, Yotnda P, Creighton CJ, Chan WY, Wong LJ. "Crosstalk from non-cancerous mitochondria can inhibit tumor properties of metastatic cells by suppressing oncogenic pathways.." PLoS ONE. 2013;8(5):e61747. Pubmed PMID: 23671572
• Tang S, Wang J, Zhang VW, Li FY, Landsverk M, Cui H, Truong CK, Wang G, Chen LC, Graham B, Scaglia F, Schmitt ES, Craigen WJ, Wong LJ. "Transition to next generation analysis of the whole mitochondrial genome: a summary of molecular defects.." Hum. Mutat.. 2013 June;34(6):882-93. Pubmed PMID: 23463613
• Cui H, Li F, Chen D, Wang G, Truong CK, Enns GM, Graham B, Milone M, Landsverk ML, Wang J, Zhang W, Wong LJ. "Comprehensive next-generation sequence analyses of the entire mitochondrial genome reveal new insights into the molecular diagnosis of mitochondrial DNA disorders.." Genet. Med.. 2013 May;15(5):388-94. Pubmed PMID: 23288206
• Wang J, Cui H, Lee NC, Hwu WL, Chien YH, Craigen WJ, Wong LJ, Zhang VW. "Clinical application of massively parallel sequencing in the molecular diagnosis of glycogen storage diseases of genetically heterogeneous origin.." Genet. Med.. 2013 February;15(2):106-14. Pubmed PMID:  22899091
• Zhang W, Cui H, Wong LJ. "Comprehensive one-step molecular analyses of mitochondrial genome by massively parallel sequencing.." Clin. Chem.. 2012 September;58(9):1322-31. Pubmed PMID: 22777720
• Landsverk ML, Douglas GV, Tang S, Zhang VW, Wang GL, Wang J, Wong LJ. "Diagnostic approaches to apparent homozygosity.." Genet. Med.. 2012 October;14(10):877-82. Pubmed PMID: 22595940
• Lee IC, El-Hattab AW, Wang J, Li FY, Weng SW, Craigen WJ, Wong LJ. "SURF1-associated leigh syndrome: A case series and novel mutations.." Hum. Mutat.. 2012 August;33(8):1192-200. Pubmed PMID: 22488715
• Milone M, Benarroch EE, Wong LJ. "POLG-related disorders: Defects of the nuclear and mitochondrial genome interaction.." Neurology. 2011 November 15;77(20):1847-52. Pubmed PMID: 22084276