Amy Marie Breman, PhD

ABMG Certified Clinical Cytogeneticist



Assistant Professor
Molecular and Human Genetics
Baylor College of Medicine
Houston, TX, US

Senior Laboratory Director
Cytogenetics & Microarray Laboratories
Baylor Genetics


MS from Indiana University School Of Medicine
01/2004 - Indianapolis, IN, United States

PhD from Indiana University School Of Medicine
01/2007 - Indianapolis, IN, United States

BS from Purdue University
05/2001 - West Lafayette, Indiana, United States


Clinical Cytogenetics
American Board of Medical Genetics

Board Certified Clinical Cytogeneticist
American Board of Medical Genetics


• Bi W, Breman A, Shaw CA, Stankiewicz P, Gambin T, Lu X, Cheung SW, Jackson LG, Lupski JR, Van den Veyver IB, Beaudet AL. "Detection of =1Mb microdeletions and microduplications in a single cell using custom oligonucleotide arrays." Prenat. Diagn.. 2012 January;32(1):41567. Pubmed PMID: 22470934
• Breman AM, Probst FJ, Blazo MA, Schaaf CP, Roney EK, Craigen WJ, Bacino CA, Cheung SW. "Identification of complex chromosome 18 rearrangements by FISH and array CGH in two patients with apparent isochromosome 18q." Am. J. Med. Genet. A. 2011 June;155(6):1465-8. Pubmed PMID: 21567909
• Breman AM, Ramocki MB, Kang SH, Williams M, Freedenberg D, Patel A, Bader PI, Cheung SW. "MECP2 duplications in six patients with complex sex chromosome rearrangements." Eur. J. Hum. Genet.. 2011 April;19(4):409-15. Pubmed PMID: 21119712
• Breman A, Pursley AN, Hixson P, Bi W, Ward P, Bacino CA, Shaw C, Lupski JR, Beaudet A, Patel A, Cheung SW, Van den Veyver I. "Prenatal chromosomal microarray analysis in a diagnostic laboratory; experience with >1000 cases and review of the literature." Prenat. Diagn.. 2012 April;32(4):351-61. Pubmed PMID: 22467166
• Breman AM, Bi WM, Cheung SW. "Prenatal diagnosis by array-based comparative genomic hybridization in the clinical laboratory setting." Beijing Da Xue Xue Bao. 2009 August 18;41(4):500-4. Pubmed PMID: 19727248
• Breman A, Patel A. "Preparation of chorionic villus samples for metaphase chromosome analysis and chromosomal microarray analysis." Curr Protoc Hum Genet. 2012 October:Unit8.3. Pubmed PMID: 23074072
• Bi W, Breman AM, Venable SF, Eng PA, Sahoo T, Lu XY, Patel A, Beaudet AL, Cheung SW, White LD. "Rapid prenatal diagnosis using uncultured amniocytes and oligonucleotide array CGH." Prenat. Diagn.. 2008 October;28(10):943-9. Pubmed PMID: 18792925
• Oshima J, Magner DB, Lee JA, Breman AM, Schmitt ES, White LD, Crowe CA, Merrill M, Jayakar P, Rajadhyaksha A, Eng CM, del Gaudio D. "Regional genomic instability predisposes to complex dystrophin gene rearrangements." Hum. Genet.. 2009 September;126(3):411-23. Pubmed PMID: 19449031
• Breman AM, Steiner CM, Slee RB, Grimes BR. "Input DNA ratio determines copy number of the 33 kb Factor IX gene on de novo human artificial chromosomes." Mol. Ther.. 2008 February;16(2):315-23. Pubmed PMID: 18059371
• Ou Z, Stankiewicz P, Xia Z, Breman AM, Dawson B, Wiszniewska J, Szafranski P, Cooper ML, Rao M, Shao L, South ST, Coleman K, Fernhoff PM, Deray MJ, Rosengren S, Roeder ER, Enciso VB, Chinault AC, Patel A, Kang SH, Shaw CA, Lupski JR, Cheung SW. "Observation and prediction of recurrent human translocations mediated by NAHR between nonhomologous chromosomes." Genome Res.. 2011 January;21(1):33-46. Pubmed PMID: 21205869
• El-Hattab AW, Skorupski JC, Hsieh MH, Breman AM, Patel A, Cheung SW, Craigen WJ. "OEIS complex associated with chromosome 1p36 deletion: A case report and review." Am. J. Med. Genet. A. 2010 February;152(2):504-11. Pubmed PMID: 20101692
• Oshima J, Lee JA, Breman AM, Fernandes PH, Babovic-Vuksanovic D, Ward PA, Wolfe LA, Eng CM, Del Gaudio D. "LCR-initiated rearrangements at the IDS locus, completed with Alu-mediated recombination or non-homologous end joining." J. Hum. Genet.. 2011 July;56(7):516-23. Pubmed PMID: 21593745
• Grimes BR, Steiner CM, Merfeld-Clauss S, Traktuev DO, Smith D, Reese A, Breman AM, Thurston VC, Vance GH, Johnstone BH, Slee RB, March KL. "Interphase FISH demonstrates that human adipose stromal cells maintain a high level of genomic stability in long-term culture.." Stem Cells Dev.. 2009 June;18(5):717-24. Pubmed PMID: 18754715
• Liang Z, Breman AM, Grimes BR, Rosen ED. "Identifying and genotyping transgene integration loci.." Transgenic Res.. 2008 October;17(5):979-83. Pubmed PMID: 18612840
• Wat MJ, Shchelochkov OA, Holder AM, Breman AM, Dagli A, Bacino C, Scaglia F, Zori RT, Cheung SW, Scott DA, Kang SH. "Chromosome 8p23.1 deletions as a cause of complex congenital heart defects and diaphragmatic hernia.." Am. J. Med. Genet. A. 2009 August;149(8):1661-77. Pubmed PMID: 19606479